Major Intrinsically Disordered Notch2-Binding Receptor 1 (MINAR1) Reagents

Major intrinsically disordered Notch2-binding receptor 1

Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth. Negatively regulates neurite outgrowth in hippocampal neurons.

Cell membrane; Single-pass type IV membrane protein.

UPF0258 family

Widely expressed, including in breast epithelial cells and endothelial cells (at protein level). Expression is down-regulated in advanced breast tumors (at protein level).

MINAR1; KIAA1024; UBTOR; Major intrinsically disordered Notch2-binding receptor 1; Membrane integral NOTCH2-associated receptor 1; Ubiquitination and mTOR signaling protein