3',5'-Cyclic-Amp Phosphodiesterase 4D (PDE4D) Reagents

3',5'-cyclic-AMP phosphodiesterase 4D

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Acrodysostosis 2, with or without hormone resistance (ACRDYS2)

Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Cyclic nucleotide phosphodiesterase family, PDE4 subfamily

Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.

DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; PDE4D

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3', 5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.