Glucose-6-Phosphate Exchanger Slc37A4 (SLC37A4) Reagents

Glucose-6-phosphate exchanger SLC37A4

Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.

Glycogen storage disease 1B (GSD1B); Glycogen storage disease 1C (GSD1C); Glycogen storage disease 1D (GSD1D)

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Major facilitator superfamily, Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family

Mostly expressed in liver and kidney.

G6PT1; G6PT1_HUMAN; G6PT2; G6PT3; Glucose-5-phosphate transporter; Glucose-6-phosphatase; transport (glucose) protein 3; Glucose-6-phosphatase; transport (glucose-6-phosphate) protein 1; Glucose-6-phosphatase; transport (phosphate/pyrophosphate) protein 2,; Glucose-6-phosphate translocase; Glucose-6-phosphate transporter 1; GSD1b; GSD1c; GSD1d; MGC15729; Microsomal glucose-6-phosphate transporter; PRO0685; SLC37A4; Solute carrier family 37 (glucose-6-phosphate transporter); member 4; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19; TRG19

This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.