Sulfotransferase 1A2 (SULT1A2) Reagents

Sulfotransferase 1A2

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Cytoplasm.

Sulfotransferase 1 family

Aryl sulfotransferase 2; Arylamine sulfotransferase; HAST4; MGC142287; MGC142289; P PST; P-PST 2; Phenol preferring phenol sulfotransferase 2; Phenol sulfotransferase 2; Phenol-sulfating phenol sulfotransferase 2; Phenolic metabolizing (P) form of PST; ST1A2; ST1A2_HUMAN; STP2; Sulfotransferase 1A2; Sulfotransferase family cytosolic 1A phenol preferring member 2; SULT1A2; Thermostable phenol sulfotransferase; TSPST2

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described.