V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation (VSIR) Reagents

V-type immunoglobulin domain-containing suppressor of T-cell activation

Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.

Cell membrane; Single-pass type I membrane protein.

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta

Cardiovascular

B7 H5; B7H5; C10orf54; chromosome 10 open reading frame 54; DD1alpha; GI24; GI24_HUMAN; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; sisp 1; SISP1; stress induced secreted protein 1; UNQ730/PRO1412; V domain Ig suppressor of T cell activation; V set domain containing immunoregulatory receptor; V set immunoregulatory receptor; V type immunoglobulin domain containing suppressor of T cell activation; VISTA

Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane.