Epidermal Growth Factor Receptor Substrate 15-Like 1 (EPS15L1) Reagents

Epidermal growth factor receptor substrate 15-like 1

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Cell membrane; Peripheral membrane protein. Nucleus. Membrane, coated pit.

EP15R_HUMAN; epidermal growth factor receptor pathway substrate 15- ike 1; Epidermal growth factor receptor substrate 15 like 1; Epidermal growth factor receptor substrate 15-like 1; epidermal growth factor receptor substrate EPS15R; Eps15 related protein; Eps15-related protein; EPS15L1; Eps15R

Enables cadherin binding activity. Predicted to be involved in endocytosis and endosomal transport. Located in membrane.