Mediator Of Rna Polymerase Ii Transcription Subunit 25 (MED25) Reagents

Mediator of RNA polymerase II transcription subunit 25

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.

Charcot-Marie-Tooth disease 2B2 (CMT2B2); Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS)

Nucleus.

Mediator complex subunit 25 family

Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen.

ACID1; Activator interaction domain 1 protein; Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit ; ARC/mediator transcriptional coactivator subunit ARC92; ARC92; BVSYS; CMT2B2; DKFZp434K0512; FLJ10193; med25; MED25 protein; MED25_HUMAN; Mediator complex subunit 25; Mediator of RNA polymerase II transcription subunit 25; Mediator of RNA polymerase II transcription; subunit 25 homolog (S cerevisiae); Mediator of RNA polymerase II transcription; subunit 25 homolog (yeast); MGC70671; p78; prostate-derived protein 78 kDa; PTOV2; TCBAP0758

This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2.