Ww Domain-Binding Protein 11 (WBP11) Reagents

WW domain-binding protein 11

Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.

Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.

Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung.

DKFZp779M1063; MGC94547; Npw38 binding protein; Npw38 binding protein NpwBP; Npw38-binding protein; NpwBP; PPP1R165; Protein phosphatase 1 regulatory subunit 165; SH3 domain binding protein SNP70; SH3 domain-binding protein SNP70; SIPP1; SNP70; Splicing factor PQBP1 and PP1 interacting; Splicing factor that interacts with PQBP 1 and PP1; Splicing factor that interacts with PQBP-1 and PP1; WBP 11; WBP-11; Wbp11; WBP11_HUMAN; WW domain binding protein 11; WW domain-binding protein 11

This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.